Excerpt: Phrenitis implies inflammation of the brain. Madness and extreme violence are the consequences. The animal, in this condition, disregards all recognitions, and, apparently, loses all timidity. It suffers the greatest agony, and no terror can appal it. It would rejoice, could it anticipate the effects, if the mouth of a loaded cannon were pointed[18] toward itself, and would look for relief when the portfire descended upon the touch-hole. Every movement seems designed to end its own existence; but the furor has no malice in it. The creature strives only to injure himself. It may in its efforts shatter and demolish the structures which surround it; but it does so without intention. That is merely the result of its being carried away beyond the things of this world by a mighty anguish. It desires harm to no one; but it cannot remain quiescent, and endure the torment which rages within its skull.