The presented retrospective survival analysis, aims to examine patient-specific factors potentially influencing implant-prosthetic treatment. Thus, the results can give recommendations for this treatment option. During the observation period from 2003 to 2023, in total 469 patients with overall 1627 implants were analyzed by use of the MZD program and finally included into the evaluation. Statistical analysis was conducted using Kaplan-Meier method for pair-wise comparison and Cox regression for multifactorial analysis. Regarding implant-supported dental prostheses (n = 1665), a mean survival time of 14.64 ± 0.24 years and a risk of functional loss of 7.2 % were recorded. The most common complication (82 cases) was the explantation of an implant leading to con-current loss of function of the implant-supported dental prostheses. The cumulative 5-, 10-, and 15-year survival rates for all implant-supported dental prostheses were 93.1 %, 84.3 %, and 67.6 %, respectively. For the included implants (n = 1627), a mean survival time of 15.98 ± 0.20 years was calculated. Approximately 5.0 % had to be explanted, with more than half of the cas-es due to periimplantitis. After an observation period of 5, 10, and 15 years, the sur-vival rates were 96.6 %, 89.4 %, and 76.3 %, respectively. Furthermore, the patient-specific factors "jaw," "splinting," and "tumor disease" had a significant influence (p < 0.05) on the survival probability of implant-supported dental prostheses as well as on the implants themselves. Concerning “jaw”, higher survival rates were observed for implant-supported dental prostheses as well as for the implants located in the maxilla compared to those in the mandible. Splinted implant-supported dental prostheses showed significantly higher survival rates (p < 0.05) than non-splinted restorations. However, there was no significant in-fluence (p > 0.05) on the survival rate of the implants regarding the splinting of the prosthetic restoration. Nevertheless, both implant-supported dental prostheses and implants showed highly significant lower survival probabilities (p < 0.001) when included in a bridge. Moreover, significantly higher survival probabilities (p < 0.05) were recorded for implant-supported dental prostheses and implants in healthy patients compared to patients after oral cancer therapy. Prosthetic restorations in tumor patients after surgi-cal jaw reconstruction exhibited higher survival probabilities than those without reconstruc-tion. This highlights the clinical benefit of jaw reconstruction for prosthetic rehabilita-tion. The good and promising survival probabilities of implant-supported dental prostheses and implants in this retrospective survival analysis emphasize the importance and relevance of implant therapy in modern dentistry. Based on the findings of this study and considering patient-specific factors, treatment recommendations for future prosthetic restorations using implants can be given. On the one hand, implant-supported dental prostheses should be splinted in order to ensure stress distribution during functional loading. On the other hand, a restitutio ad integrum treatment in which every lost tooth is replaced by a single implant can be beneficial, because of avoiding a bridge with bad survival probability. Nevertheless, this has to be discussed with the patient under financial aspects.