Seminar paper from the year 2018 in the subject Medicine - Pathology, grade: 1, Egerton University, language: English, abstract: Schizophrenia has emerged as one of the most debilitating psychiatric disorders, and it impacts on an individuals quality of life. Its prevalence is approximately 1.0%, whereas its incidence ranges from 0.16 to 0.42/1000 individuals. Evidence indicates that genetics have an integral role in the onset of schizophrenia. Some of genes involved in the development of schizophrenia include RELN gene, GRM3 gene, COMT gene, and NOS1AP gene. Similarly, neurological dysfunctions including dopamine and glutamate dysfunction have been identified as some of the main factors underlying the pathophysiology of the disorder. Overall, there is evidence that support the biological basis of schizophrenia.