This book describes the molecular biology, pathogenesis, epidemiology, and potential strategies for control of chikungunya virus (CHIKV) infection. It offers insight into the structure and functions of CHIKV proteins as they relate to host response, interaction with the arthropod vector, and vaccination. A detailed account of both the epidemiological outlook and the clinical syndrome of CHIKV infection is provided. The complex host-virus interaction and the signaling pathways that mediate such interactions are also covered. Throughout the book, graphics and charts are used to provide stimulating discussion on important findings in the field of chikungunyalogy. The chapters are written with a global perspective by experts of CHIKV from around the world. This project is especially significant given that CHIKV is a pathogen of worldwide public health concern. Although the presence of CHIKV infection is not global yet, worldwide dissemination is predicted in the future due largely to the lack of effective treatment/therapy, efficient control of transmission, and knowledge about mechanisms of pathogenesis. Additionally, globalization of CHIKV is predicated on its mode of dissemination (mosquito vector) and cross border travel and migration.

Chioma M. Okeoma, Ph.D

Department of Microbiology

Carver College of Medicine

University of Iowa

Clinical Syndrome and Therapy.- Host Response and Mechanisms of Subversion of Chikungunya.- Epidemiological History of Chikungunya Virus.- Vaccines Against Chikungunya Virus Infection.- Function of Chikungunya Virus Structural Proteins.- Functions of Chikungunya Virus Nonstructural Proteins.- Interaction of Chikungunya Virus with the Mosquito Vector.- Chikungunya Virus Entry and Replication.- Chikungunya Virus-Induced Autophagy and Apoptosis.- Chikungunya Virus Pathogenesis.- Restriction Factors and Chikungunya Virus.