Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall.  In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases --  primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others.  This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients.  Developed by a renowned group of authors,Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases.  This volume will again be a must-read for clinicians at all levels, investigators andstudents.

Introductory Comments

About the authors

Preface            Meeting the Challenge of Patients with Immune Mediated Liver Disease

                        Keith D. Lindor, keith.lindor@asu.edu

Foreword:        Contemporary Liver Immunology and Immunopathology:  Obstacles and Opportunities

                        Ian R. Mackay, ian.mackay@monash.edu

Chapter 1:        Core concepts in immunology

                        Cliona O'Farrelly& Derek Doherty

Chapter 2:        The Geoepidemiology of Autoimmune Liver Disease

Carlo Selmi, Cecilia B. Chighizola, Angela Ceribelli, Maria De Santis, Pier Luigi Meroni,& Renqian Zhong

Chapter 3:        Diagnostic Liver Immunology

                        Christopher Bowlus

Chapter 4:        The Liver as a Lymphoid Organ

                        Percy Knolle

Chapter 5:        Innate Immunity and Disorders of the Liver

Mathias Heikenwalder, Percy Knolle,& U. Protzer

Chapter 6:        The Liver and Immune Tolerance

                        Zhigang Tian, Cai Zhang,& Zhe-Xiong Lian

Chapter 7:        The Diagnosis and Classification of Immune Mediated Hepatic

                        Diseases

                        F. Alvarez

Chapter 8:        The Diagnosis and Classification of Immune Mediated Biliary Diseases

                        Gideon Hirschfield

Chapter 9:        Bacterial Infections in Liver

                        Eirini I. Rigopoulou, Daniel S. Smyk, Timoklia Orfanidou, Dimitrios Bogdanos,&

                        M. Eric Gershwin

Chapter 10:      The Diagnosis and Classification of Parasitic Diseases of the Liver

                        Shyamapada Mandal& Manisha Mandal

Chapter 11:      Viral Diseases of the Liver

                        Gadi Lalazar& Yaron Ilan

Chapter 12:      Hepatitis A: Immune response and virus evolution

                        Rosa M. Pinto, Albert Bosch,& Gerardo Kaplan

Chapter 13:      Immunopathogenesis of Chronic Hepatitis B and the Clinical

                        Events that Shape its Natural History

                        Stevan A. Gonzalez& Robert P. Perrillo

Chapter 14:      Hepatitis C

                        Mario U. Mondelli, Stefania Varchetta,& Francesco Negro

Chapter 15:      Immunopathogenesis of Hepatitis D

Sebastian Luneman, Jan Grabowski,& Heiner Wedemeyer

Chapter 16:      Hepatitis E

                        Hiroki Takahashi& Mikio Zeniya

Chapter 17:      Primary Biliary Cirrhosis

                        Pietro Invernizzi, Patrick S.C. Leung, Ma Xiong,& M. Eric Gershwin,

Chapter 18:      Autoimmune Hepatitis

                        Diego Vergani, Rodrigo Liberal,& Giorgina Mieli-Vergani

Chapter 19:      Primary Sclerosing Cholangitis

                        Harald Hofer, Emina Halibasic, Katharina Staufer& Michael Trauner,

Chapter 20:      Overlap Syndromes

                        Said Al Mamari, Roger Chapman& Kirsten Muri Boberg,

Chapter 21:      Alcoholic Liver Disease

                        Gyongyi Szabo

Chapter 22:      Non-Alcoholic Fatty Liver Disease

                        Arun Sanyal&             Vaishali Patel

Chapter 23:      Pediatric Liver Disease

                        Giorgina Mieli-Vergani, Rodrigo Liberal& Diego Vergani

Chapter 24:      Mechanisms of Acute Liver Failure

                        Christian Trautwein& Alexander Koch

Chapter 25:      Non-Immune Mediated Drug Induced Hepatotoxicity

                        Christian Strassburg

Chapter 26:      Immune-Mediated Drug Induced Liver Injury

                        Einar S. Bjornsson& Guruprasad Aithal

Chapter 27:      The Immunopathogenesis of Cirrhosis

                        Bin Gao, Scott L. Friedman& Wajahat Z. Mehal

Chapter 28:      Graft vs. Host Disease

                        John Vierling& Ali Raza

Chapter 29:      Immune-mediated liver disease in the transplantated liver

                        Palak Jitendrakumar Trivedi, Ka-Kit Li& James Neuberger,

Chapter 30:      The future of liver immunology

                        M. Eric Gershwin, John Vierling& Michael Manns