This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubilityin silico andin vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.

Christoph Saal, Merck KGaA, Darmstadt, Germany

Anita Nair, Merck KGaA, Darmstadt, Germany