This book is useful to engineers, researchers, entrepreneurs, and students in different branches of production, engineering, and systems sciences. The polytopic roadmaps are the guidelines inspired by the development stages of cognitive-intelligent systems, and expected to become powerful instruments releasing an abundance of new capabilities and structures for complex engineering systems implementation. The 4D approach developed in previous monographs and correlated with industry 4.0and Fourth Industrial Revolution is continued here toward higher dimensions approaches correlated with polytopic operations, equipment, technologies, industries, and societies. Methodology emphasizes the role of doubling, iteration, dimensionality, and cyclicality around the center, of periodic tables and of conservative and exploratory strategies. Partitions, permutations, classifications, and complexification, as polytopic chemistry, are the elementary operations analyzed. Multi-scale transfer, cyclic operations, conveyors, and assembly lines are the practical examples of operations and equipment. Polytopic flow sheets, online analytical processing, polytopic engineering designs, and reality-inspired engineering are presented. Innovative concepts such as Industry 5.0, polytopic industry, Society 5.0, polytopic society, cyber physical social systems, industrial Internet, and digital twins have been discussed. The general polytopic roadmaps, (GPTR), are proposed as universal guidelines and as common methodologies to synthesize the systemic thinking and capabilities for growing complexity projects implementation.