Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders are explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.

The Laboratory Bench.- Introduction: Inflammatory bowel disease: from bench to bedside.- The changing faces of Crohns disease and ulcerative colitis.- Genetics of inflammatory bowel disease.- Experimental mouse models of inflammatory bowel disease: new insights into pathogenic mechanisms.- The normal intestinal mucosa: a state of controlled inflammation.- The lymphocyte-epithelial-bacterial interface.- The mucosal inflammatory response. Cytokines and chemokines.- Role of the microcirculation in chronic gut inflammation.- Remission, relapse, intestinal healing and repair.- Antibodies in the exploration of inflammatory bowel disease pathogenesis and disease stratification.- Pathophysiology of inflammatory bowel disease: the effect of inflammation on intestinal function.- Systemic consequences of intestinal inflammation.- The Bedside.- Understanding symptoms and signs in inflammatory bowel disease.- Clinical course and complications of ulcerative colitis and ulcerative proctitis.- Clinical features and complications of Crohns disease.- Mechanisms of systemic inflammation associated with intestinal injury.- Pathology of inflammatory bowel disease: a critical appraisal in diagnosis and management.- An endoscopic and histologic perspective of diagnosis: when, where, and what to do.- Radiologic (radiographic) and imaging features of ulcerative colitis and Crohns disease.- New diagnostic approaches in inflammatory bowel disease.- Differential diagnosis of colitis.- Disease management in chronic medical conditions.- Pharmacoeconomics and inflammatory bowel disease.- Measuring quality of life in inflammatory bowel disease.- Clinical pharmacology in inflammatory bowel disease: optimizing current medical therapy.- Multi-site therapeutic modalities forinflammatory bowel diseases mechanisms of action.- Targeted therapies for inflammatory bowel disease.- Role of antibiotics and probiotics in the management of inflammatory bowel disease.- Nutrition in inflammatory bowel disease.- Medical management of ulcerative colitis.- Surgical management of ulcerative colitis.- Pouchitis: clinical characteristics and management.- Medical therapy for Crohns disease.- Surgery for Crohns disease.- Postoperative prevention of recurrence of Crohns disease.- The molecular pathology of inflammatory bowel disease-associated neoplasia and preneoplasia.- Dysplasia in inflammatory bowel disease: clinical pathology and current surveillance methods.- Hepatobiliary disorders.- Articular and ocular complications of inflammatory bowel disease.- Cutaneous manifestations of inflammatory bowel disease.- Fertility and pregnancy in inflammatory bowel disease.- Special considerations in the diagnosis and management of inflammatory bowel disease in the pediatric age group.- Microscopic colitis: collagenous and lymphocytic colitis.- Colon ischemia.- Diversion colitis.- Pseudomembranous colitis and Clostridium difficile infection.- Infectious colitis.- Human Immunodeficiency virus and inflammatory bowel disease.- Bone metabolism and inflammatory bowel disease.- Back to the Laboratory Bench.- Epilogue: Bench to bedside and back to bench.