Within the scope of the present work, a novel laser texturing processing to optimize the surface characteristics of dental titanium implants is developed. The treatment with ultrashort pulsed laser for the surface texturing shows promising results to prevent implant-associated infections on dental implants. On the one hand, this is achieved by reducing the biofilm formation of the pioneer bacteria Streptococcus. The reduction of biofilm formation on the surface avoids the proliferation of pathogen bacteria responsible for the peri-implantitis disease. On the other hand, the host tissue integration is achieved through the adhesion of human MSCs, allowing the maintenance of biocompatibility. The investigation of both aspects within the same framework conditions comprises a method to assess the technology developed to prevent the occurrence of peri-implantitis cases without compromising the biocompatibility of the implant.