The largest high-level encyclopedia on molecular medicine is now publishing a topical volume on Nanomedicine. The long awaited volume gives a comprehensive overview on nanomaterials in drug delivery, imaging and as therapeutics.

Robert A. Meyers obtained his Ph.D. in Chemistry at the University of California at Los Angeles. He was a post-doctoral fellow at the California Institute of Technology and has more than 17 patents, 50 technical papers and 12 books to his name. As Editor-in-Chief he conceived and edited several ambitious multivolume reference works, e.g. the Encyclopedia of Analytical Chemistry (Wiley), the Encyclopedia of Molecular Biology and Molecular Medicine (Wiley-VCH) and the Encyclopedia of Physical Science and Technology (Academic Press).

Preface vii

Part I Laboratory Techniques1

1 Microfluidics in Nanomedicine 3YongTae Kim and Robert Langer

2 Quantum Dots for Biomedical Delivery Applications 29Abolfazl Akbarzadeh, Sedigheh Fekri Aval, Roghayeh Sheervalilou, Leila Fekri, Nosratollah Zarghami, and Mozhdeh Mohammadian

Part II Devices43

3 DNA Origami Nanorobots 45Ido Bachelet

4 Graphene and Graphene Derivatives in Biosensing, Imaging, Therapeutics, and Genetic Engineering 71KimTruc Nguyen and Yanli Zhao

5 Synthetic Gene Circuits 107Barbara Jusiak, Ramiz Daniel, Fahim Farzadfard, Lior Nissim, Oliver Purcell, Jacob Rubens, and Timothy K. Lu

6 Synthetic Hybrid Biosensors 163Apoorv Shanker, Kangwon Lee, and Jinsang Kim

Part III Pharmaceutical Delivery199

7 Carbon Nanotubes for Enhanced Biopharmaceutical Delivery 201Harikrishna Rallapalli and Bryan Ronain Smith

8 Cholesterol in Nanobiotechnology 227Philipp Schattling, Yan Zhang, Boon M. Teo, and Brigitte Städler

9 Nanoparticle Conjugates for Small Interfering RNA Delivery 279Timothy L. Sita and Alexander H. Stegh

10 Role of Scavenger Receptors in Immune Recognition and Targeting of Nanoparticles 305Guankui Wang and Dmitri Simberg

Part IV Cancer329

11 Gold and Iron Oxide Nanoparticles with Antibody Guides to Find and Destroy Cancer Cells 331Stephanie A. Parker, Isabel A. Soto, Dickson K. Kirui, Cameron L. Bardliving, and Carl A. Batt

12 RNA Interference in Cancer Therapy 357Barbara Pasculli and George A. Calin

13 Smart Nanoparticles in Brain Cancer Therapy 411Yinhao Wu, Tao Sun, Lisha Liu, Xi He, Yifei Lu, Sai An, and Chen Jiang

Part V Tissue Engineering and Regeneration 429

14 Bone Tissue Engineering: Nanomedicine Approaches 431Michael E. Frohbergh, Peter Newman, Calogera M. Simonaro, and Hala Zreiqat

Index 457