This completely revised and updated fourth edition of the best-selling classic is a thorough treatment of the subject while remaining concise and readable. New additions include capillary electrophoresis, monolithic columns, zwitterion colums, DNA/RNA analysis, fundamentals of the science of IC, and micro methods. The whole is rounded off by handy tables with details on detection or elution conditions, among others.

After having obtained his Ph.D. in 1948 by the University of Illinois, Professor James S. Fritz became Senior Chemist and Professor of Chemistry at Iowa State University in 1960. He was named Distinguished Professor in Liberal Arts and Sciences in 1990. Besides Ion Chromatography his research interests are titrations, solid-phase extractions, capillary electrophoresis and analytical complexing reagents. He has authored or coauthored several scientific books, including Fritz and Gjerde's "Ion Chromatography", now in its 4th printing. In addition, he has published more than 325 scientific publications. Douglas T. Gjerde received his PhD in analytical chemistry from Iowa State University. After having worked in large and small companies for a number of years, Gjerde founded Sarasep, Inc. in 1990 for the commercialization of polymeric separation technologies and co-founded Transgenomic, Inc. in 1997 for the commercialization of nucleic acid separation technology. He is now working on his third start-up company, PhyNexus, Inc. PhyNexus produces miniaturized sample preparation tools for the biological research market. Gjerde has authored and coauthored numerous articles, book chapters and 5 books and holds over fifty patents in separation science.

INTRODUCTION AND OVERVIEW Introduction Historical Development Principles of Ion Chromatographic Separation and Detection INSTRUMENTATION Components of an Ion Chromatograph (IC) Instrument General Considerations Eluent Pump Sample Injector Columns Suppressor Detector Data Acquisition and Calculation of Results RESINS AND COLUMNS Introduction Polymeric Resins Resins and Columns for Ion Chromatography Anion Exchangers Cation Exchangers Other Resins DETECTORS Introduction Conductivity Detectors Ultraviolet-Visible (UV-Vis) Detectors Fluorescence Detector Electrochemical Detectors Refractive Index Detector Evaporative Light Scattering Detector (ELSD) Other Detectors PRINCIPLES OF ION CHROMATOGRAPHIC SEPARATIONS General Considerations Chromatographic Terms Selectivity Chromatographic Efficiency ANION CHROMATOGRAPHY Scope and Conditions for Separation Suppressed Anion Chromatography Nonsuppressed Ion Chromatography Coated Columns Optical Absorbance Detection Detection Pulsed Amperometric Detector (PAD) Evaporative Light Scattering Detector (ELSD) Inductively Coupled Plasma Methods (ICP) CATION CHROMATOGRAPHY Introduction Columns Separations Effect of Organic Solvents Separation of Metal Ions with a Complexing Eluent Chelating Ion-Exchange Resins and Chelation Ion Chromatography ION-EXCLUSION CHROMATOGRAPHY Principles Separation of Organic Acids Simultaneous Determination of Anions and Cations Conclusions Determination of Carbon Dioxide and Bicarbonate Separation of Bases Determination of Water Separation of Saccharides and Alcohols ION PAIR CHROMATOGRAPHY Principles Typical Separations Mechanism ZWITTERION STATIONARY PHASES Introduction Simultaneous Separation of Anions and Cations Separation of Anions Separation of Cations Mechanism CAPILLARY ELECTROPHORESIS Introduction Principles Electroosmotic Flow (EOF) Separations of Ions Capillary Electrophoretic Ion Chromatography DNA AND RNA CHROMATOGRAPHY Introduction DNA and RNA Chemical Structure and Properties DNA and RNA Chromatography Temperature Modes of DNA and RNA Chromatography Instrumentation Applications of DNA Chromatography Applications of RNA Chromatography SAMPLE PRETREATMENT Dilute and Shoot or Pre-Treat the Sample? Particulate and Column-Contaminating Matter Preconcentration Sample Pretreatment METHOD DEVELOPMENT AND VALIDATION Choosing a Method Some Applications of Ion Chromatography Statistical Evaluation of Data Validation of Analytical Procedures CHEMICAL SPECIATION Introduction Detection Chromatography Valveless Injection IC Speciation of Some Elements