This book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature. Acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. Chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. The text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. The second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. The final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. Chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes. This is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the ICU.

Janet S. Lee Associate Professor of Medicine Division of Pulmonary, Allergy, Critical Care Medicine University of Pittsburgh Pittsburgh, PA 15213

Part I: Overview.- The Lung-Blood Interface.- Leukocyte Kinetics and Migration in the Lungs.- Part II: Acute Pulmonary Manifestations Arising from Primary Hematologic Disorders.- Sickle Cell and Acute Chest Syndrome: Mechanisms and Pathogenesis.- Sickle Cell Disease and Acute Chest Syndrome: Epidemiology, Diagnosis, Management, Outcomes.- Thrombophilias and Acute Pulmonary Thromboembolic Disease.- Bleeding Disorders: Diagnosis and Treatment of Hemorrhagic Complications in the Intensive Care Unit.- Acute Pulmonary Manifestations of Hematologic Malignancies.- Acute Pulmonary Complications of Bone Marrow and Stem Cell Transplantation.- Part III: Transfusion-Related Complications.- Storage Lesion: Evolving Concepts and Controversies.- Transfusion and Acute Respiratory Distress Syndrome: Pathogenesis and Potential Mechanisms.- Transfusion and Acute Respiratory Distress Syndrome: Clinical Epidemiology, Diagnosis, Management, and Outcomes.- Transfusion Associated Circulatory Overload.- Transfusion-Related Immunomodulation (TRIM): From Renal Allograft Survival to Postoperative Mortality in Cardiac Surgery.