This book constitutes the refereed proceedings of the 41st International Conference on Conceptual Modeling, ER 2022, held in Hyderabad, India, in October 2022. The 19 full and 11 short papers were carefully reviewed and selected from 82 submissions. The papers are organzed in the following topical sections: foundations of conceptual modeling; ontologies and their applications; applications of conceptual modeling; data modeling and analysis; business process; quality and performance; security, privacy and risk management; goals and requirements.