This monograph is dedicated to the lives and scientific achievements of the physiology pioneers Warren and Margaret Lewis. Their story spans the first half of the 20th century, from their respective educations through early, independent research to joint research from 1910 to 1955. Among the numerous developments they initiated, were the discovery of pinocytosis, the beginnings of video microscopy and the development of the first mammalian tissue cultures. Their research expanded the theoretical knowledge of cell structure and function. On a more practical level, they advanced many laboratory methods, like the first recipes for culture media. The text is beautifully enriched with personal anecdotes about their lives.

This is the story of two scientific pioneers in the context of early 20th century biology and physiology. It is an inspiration for senior and aspiring researchers.

After receiving his Ph.D. from Stanford University in 1967, Dr. Evans did research at the University of Lancaster (UK) and Station Zoologique at Villefranche-sur-mer (FR). He served on the faculty at the University of Miami (1969-1981) and University of Florida (1981-2007). He was also a Principal Investigator at the Mt. Desert Island Biological Laboratory from 1978-2010. His research interests center on the roles of the gills in fish osmoregulation. He is a Fellow of the AAAS and APS, has received both the August Krogh Distinguished Lectureship and the William Hoar Lectureship, and the University of Florida Teacher/Scholar of the Year Award.

Warren Lewis: Early Life, Educational Background, and Early Research.- Margaret Reed: Early Life, Educational Background, and Early Research.- Early Collaborative Research.- Move to Carnegie Institution.- Research and Family Life in the Early 1920s.- Research in the Late 1920s.- Warrens Research in the 1930s.- Margarets Research in the 1930s.- Impact, Accolades, and a Cottage in Maine.- Research after Warrens Retirement.- Final Years: The End of Research, but not Honors.