This book constitutes the proceedings of the 6th International Conference on Digital Economy, ICDEc 2021. The conference was held during July 15-17, 2021. It was initially planned to take place in Tallin, Estonia, but changed to a virtual event due to the COVID-19 pandemic.The 18 papers presented in this volume were carefully reviewed and selected from 51 submissions. They were organized in topical sections as follows: Digital strategies; virtual communities; digital assets and blockchain technology; artificial intelligence and data science; online education; digital transformation; and augmented reality and IOT.