This volume is designed to feature the pharmacology of new psychoactive substances, legislative aspects, information exchange including epidemiology, and clinical, forensic, and analytical toxicology in order to facilitate the understanding of this complex and rapidly developing phenomenon.

Preface.- Part I General Aspects.- 1. Self-Experiments with Psychoactive Substances: A Historical Perspective.- 2. Responding to New Psychoactive Substances in the European Union: Early Warning, Risk Assessment, and Control Measures.- 3. Emergence, Diversity, and Control of New Psychoactive Substances: A Global Perspective.- 4. Epidemiology of NPS Based Confirmed Overdose Cases: The STRIDA Project.- Part II Drug Classes.- 5. Neuropharmacology of Synthetic Cathinones.- 6. Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances.- 7. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substances: Origins.- 8. Molecular pharmacology of synthetic cannabinoids: Evolution.- 9. Synthetic Opioids.- 10. Designer Benzodiazepines: Another Class of New Psychoactive Substances.- 11. Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action.- 12. 1,2-Diarylethylamine- and Ketamine-Based New PsychoactiveSubstances.- 13. Phencyclidine-Based New Psychoactive Substances.- Part III Clinical, Forensic, and Analytical Toxicology.- 14. Bioanalytical Methods for New Psychoactive Substances.- 15. Wastewater Analysis for Community-Wide Drugs Use Assessment.- 16. Toxicokinetics of NPS: Update 2017.- 17. Patterns of Acute Toxicity Associated with New Psychoactive Substances.- 18. Fatal Poisonings Associated with New Psychoactive Substances.