A comprehensive guide to multiple sclerosis, discussing: clinical features, diagnosis, disease-modifying therapy,& symptom& medical management written by world-renowned experts in neurology, specifically MS. Dr Cohen and Dr Rae-Grant who are renowned researchers and physicians in the field of MS and are investigators on several key drug trials.

Extensive use of illustrations and succinct format makes this book an easily accessible and key reference guide.

Reviews cutting-edge agents currently in development, while also discussing the clinical features and standard diagnosing criteria and practices of MS from the clinicians perspective

Designed to include thorough descriptions of standard and novel treatment therapies in MS.

Explains how to most effectively use the top therapies in MS in the context of a clinical practice and based on investigational trials.

Concise but comprehensive

Over the past 30 years, there have been significant advances in our understanding of MS due to the use of MRIs to better visualize the disease and due to the introduction of new ameliorating drugs. However, MS is still an incurable disease and diagnosis remains challenging for many physicians; for instance, symptoms often mimic MS, and there is no specific test for the disease. To ensure optimal patient care, there is a need for physicians to remain up to date with new drugs on the market, disease detection, diagnosis, and latest management options.

TheHandbook of Multiple Sclerosis provides a concise, easilyaccessible guide for all healthcare professionals involved in the diagnosis and management of this condition, including standard therapies, as well as more novel treatments. The book will also include comprehensive evaluations of the pharmacological treatments available, including novel investigational agents currently in development.

Jeffrey A Cohen MDis Professor of Medicine (Neurology) in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and has worked at the Cleveland Clinics Mellen Center for Multiple Sclerosis Treatment and Research since 1994. Dr Cohen received his BA in Zoology from Connecticut College in 1976 and MD from the University of Chicago Pritzker School of Medicine in 1980. He completed a neurology residency in 1984, then a 3-year neuroimmunology fellowship with Robert Lisak MD and Mark Greene MD at the University of Pennsylvania. He was on the faculty in the department of neurology at the University of Pennsylvania from 1987 to 1994. Dr Cohens research interests included autoimmune mechanisms, anti-viral immunity, lymphocyte activation, and glial biology as they relate to multiple sclerosis (MS). Dr Cohen moved to the Cleveland Clinic in 1994 to direct the Mellen Centers Experimental Therapeutics Program. He has been involved in various capacities in a large number of clinical trials developing new therapies for MS. In addition, he has helped develop new clinical and imaging endpoints for MS trials. At the Mellen Center, Dr Cohen also directs the Clinical Neuroimmunology Fellowship that has trained a number of MS clinical investigators. Finally, Dr Cohen has a large clinical practice devoted to the diagnosis and management of MS and related disorders.

Alexander Rae-Grant, MD FRCPis a staff neurologist at the Cleveland Clinic. After receiving his Bachelor of Arts in biochemistry and molecular biology from Yale in 1979, he graduated from McMaster University Medical School in 1982. He completed 2 years of internal medicine at the University of Toronto then a neurology residency at the University of Western Ontario in 1987. Dr Rae-Grant joined the Cleveland Clinics Mellen Center for Multiple Sclerosis Treatment and Research in 2007, where he is engaged in patient care and clinical trials anddirects the patient and professional educational efforts. He is active in medical student, resident, and fellow training and co-directs the neurosciences clinical clerkship in the Cleveland Clinic Lerner College of Medicine. Dr Rae-Grant was recently honored as Teacher of the year for the Neurology Department at the Cleveland Clinic. He authored the neurology textbookNeurology for the House Officerand co-editedThe 5-Minute Consultin Neurology.