Coronary Artery Disease is directed towards individuals with an interest in the clinical treatment of patients with unrevascularizable angina. It explores a variety of treatment options in the setting of a sound scientific background and provide guidance and predictions for future direction in this rapidly developing field. It fulfills an unmet need and is greeted with significant enthusiasm by the practicing internal medicine, family practice and cardiovascular clinicians. It also provides a reliable reference for clinical and basic researchers interested in this topic, as well as affected patients and their families.

Epidemiology of Cardiovascular Disease and Refractory Angina.- Basic Science Concepts.- Natural History in Humans.- Therapeutic Goals in Patients with Refractory Angina.- Medical Therapy for Chronic Refractory Angina.- External Counterpulsation.- Transmyocardial Laser Revascularization.- Invasive and Device Management of Refractory Angina.- Cardiac Transplantation for Ischemic Heart Disease.- Alternative Therapies for Chronic Refractory Coronary Artery Disease.- Nonspecific Placebo Effects.- Prognostic Implication of Depression in Ischemic Syndromes