Principles of Virology is the leading virology textbook because it does more than collect and present facts about individual viruses. Instead, it facilitates an understanding of basic virology by examining the shared processes and capabilities of viruses. Using a set of representative viruses to present the complexity and diversity of a myriad of viruses, this rational approach enables students to understand how reproduction is accomplished by known viruses and provides the tools for future encounters with new or understudied viruses.

This fully updated edition represents the rapidly changing field of virology. A major new feature is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology.

Applicable courses: undergraduate courses in virology and microbiology as well as graduate courses in virology and infectious diseases.

Volume I Molecular Biology

Part I The Science of Virology

1 Foundations

2 The Infectious Cycle

Part II Molecular Biology

3 Genomes and Genetics

4 Structure

5 Attachment and Entry

6 Synthesis of RNA from RNA Templates

7 Reverse Transcription and Integration

8 Synthesis of RNA from DNA Templates

9 Replication of DNA Genomes

10 Processing of Viral Pre-mRNA

11 Protein Synthesis

12 Intracellular Trafficking

13 Assembly, Exit, and Maturation

14 The Infected Cell

Appendix Structure, genome organization, and infectious cycles

Glossary

Index

Volume II Pathogenesis and Control

1 Infections of Populations: History and Epidemiology

2 Barriers to Infection

3 The Early Host Response: Cell-Autonomous and Innate Immunity

4 Adaptive Immunity and the Establishment of Memory

5 Mechanisms of Pathogenesis

6 Cellular Transformation and Oncogenesis

7 Human Immunodeficiency Virus Pathogenesis

8 Vaccines

9 Antiviral Drugs

10 Evolution

11 Emergence

12 Unusual Infectious Agents

Appendix Diseases, Epidemiology, and Disease Mechanisms of Selected Animal Viruses Discussed in This Book

Glossary

Index