The Maudsley Prescribing Guidelines in Psychiatry

The new edition of the world-renowned reference guide on the use of medications for patients presenting with mental health problems

The Maudsley Prescribing Guidelines in Psychiatry is the essential evidence-based handbook on the safe and effective prescribing of psychotropic agents. Covering both common and complex prescribing situations encountered in day-to-day clinical practice, this comprehensive resource provides expert guidance on drug choice, minimum and maximum doses, adverse effects, switching medications, prescribing for special patient groups, and more. Each clear and concise chapter includes an up-to-date reference list providing easy access to the evidence on which the guidance is based.

The fourteenth edition has been fully updated to incorporate the latest available research, the most recent psychotropic drug introductions, and all psychotropic drugs currently used in the UK, USA, Canada, Australia, New Zealand, and Japan. Several new sections cover topics such as deprescribing of major psychiatric drugs, prescribing psychotropics at the end of life, the treatment of agitated delirium, the genetics of clozapine prescribing, the use of weekly penfluridol, and the treatment of psychotropic withdrawal. Featuring contributions by an experienced team of psychiatrists and specialist pharmacists, the new edition ofThe Maudsley Prescribing Guidelines in Psychiatry:

Provides succinct coverage of drug treatment of psychiatric conditions and formulating prescribing policy in mental healthCovers a wide range of psychiatric conditions including schizophrenia, bipolar disorder, depression and anxiety, borderline personality, eating disorders, and many othersProvides advice on prescribing for children and adolescents, older people, pregnant women, and other special patient groupsOffers new sections on genetic prescribing, long-acting injectable formulations, ketamine administration and uses, and dopamine super-sensitivityIncludes referenced information on off-label prescribing, potential interactions with other substances such as alcohol, tobacco, and caffeine, and treating patients with comorbid physical conditions

Whether in the doctor's office, in the clinic, or on the ward,The Maudsley Prescribing Guidelines in Psychiatry, Fourteenth Edition is a must-have for psychiatrists, pharmacists, neuropharmacologists, clinical psychologists, nurses, and other healthcare professionals working in mental health, as well as trainees and students in medicine, pharmacy, and nursing.

David M. Taylor, BSc, MSc, PhD, FFRPS, FRPharmS, FRCPsych (Hon) is Director of Pharmacy and Pathology at the Maudsley Hospital and Professor of Psychopharmacology at King's College, London.

Thomas R. E. Barnes, MBBS, MD, FRCPsych, DSc, is Emeritus Professor of Clinical Psychiatry at Imperial College London and joint-head of the Prescribing Observatory for Mental Health at the Royal College of Psychiatrists' Centre for Quality Improvement.

Allan H. Young, MB, ChB, MPhil, PhD, FRCPC, FRCPsych, is Chair of Mood Disorders and is Director of the Centre for Affective Disorders in the Department of Psychological Medicine in the Institute of Psychiatry at King's College London, UK.

Preface xi

Acknowledgments xii

Notes on using The Maudsley Prescribing Guidelines in Psychiatry xiii

List of abbreviations xv

Part 1 Drug treatment of major psychiatric conditions 1

Chapter 1 Schizophrenia and related psychoses 3

ANTIPSYCHOTIC DRUGS 3

ANTIPSYCHOTIC ADVERSE EFFECTS 109

REFRACTORY SCHIZOPHRENIA AND CLOZAPINE 190

CLOZAPINE ADVERSE EFFECTS 212

Chapter 2 Bipolar disorder 247

Chapter 3 Depression and anxiety disorders 305

Chapter 4 Addictions and substance misuse 451

Part 2 Drug treatment of special patient groups 537

Chapter 5 Children and adolescents 539

Chapter 6 Prescribing in older people 601

Chapter 7 Pregnancy and breastfeeding 679

Chapter 8 Hepatic and renal impairment 723

Part 3 Prescribing in specialist conditions 755

Chapter 9 Drug treatment of other psychiatric conditions 757

Chapter 10 Drug treatment of psychiatric symptoms occurring in the context of other disorders 777

Part 4 Other aspects of psychotropic drug use 831

Chapter 11 Pharmacokinetics 833

Chapter 12 Other substances 865

Chapter 13 Psychotropic drugs in special conditions 875

Chapter 14 Miscellany 897

Index 943