Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology

The newly revised Second Edition ofLiver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care.

Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient.Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management.

Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy:

Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation,Liver Transplantation: Clinical Assessment and Managementwill also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.

JAMES NEUBERGER, DM, FRCP is Consultant Physician in the Liver Unit, Birmingham, UK. A previous President of the British Association for the Study of the Liver, he has over 35 years of liver transplantation and disease experience and has edited five books on liver disease and liver transplantation and published extensively in liver disease and transplantation.

JAMES FERGUSON, MD, FRCPE is Consultant Hepatologist at the Queen Elizabeth Hospital in Birmingham, UK. He has extensive experience in managing patients with liver disease and in liver transplantation.

PHILIP N. NEWSOME, PHD, FRCPE is Professor of Experimental Hepatology and Honorary Consultant Hepatologist, Director of Research and Knowledge Transfer for the College of Medical& Dental Sciences and Director of the Centre for Liver and Gastrointestinal Research in the University of Birmingham, UK. Currently Secretary General of the European Association for the Study of the Liver, he continues to research in all aspects of liver disease and stem cell therapy.

MICHAEL RONAN LUCEY, MD, FRCPI is Chief of the Division of Gastroenterology and Hepatology at the University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. A past President of the American Society of Transplantation, he continues to publish widely in the field of liver disease and liver transplantation.

List of Contributors x

Foreword to the Second Edition xx

Foreword to the First Edition xxi

Preface xxii

Abbreviations xxiii

Part 1 When to Refer a Patient for Liver Transplantation1

1 Overview on Organ Donation and Liver Transplantation 3Michael Ronan Lucey

2 Predicting Outcomes and Use and Abuse of Prognostic Models 11Moira B. Hilscher and Patrick S. Kamath

Part 2 Selection, Assessment, and Management on the List19

3 Assessment of the Potential Transplant Recipient 21Michael L. Volk

4 Frailty and the Potential Liver Transplant Candidate 27Matthew J. Armstrong and Jennifer C. Lai

5 Alcohol Use (excluding Alcohol-Related Liver Disease), Tobacco, Marijuana, and Illicit Drugs 33John P. Rice

6 The Role of the Psychiatric Consultant in the Selection, Assessment, and Management of Liver Transplant Patients 39Robert M. Weinrieb and Arpita Goswami-Banerjee

7 When Liver Transplant Patients Do Not Adhere to Therapeutic Plans 48Kerry Webb and Rowena Jones

8 Liver Transplant Assessment for Young People: Addressing the Needs of Young People with Liver Disease 55Marianne Samyn and Jemma Marie Day

9 Assessment and Management of the Patient with Hepatitis C 64Emma L. Hathorn and David J. Mutimer

10 Management of Hepatitis B Virus Infection Pre Transplantation 68Bruno Roche and Didier Samuel

11 Transplantation for the Management of Malignancy 74Adiba I. Azad, Julie K. Heimbach, and Gregory J. Gores

12 Assessment and Management of the Liver Transplant Candidate with Acute-on-Chronic Liver Failure 82Giovanni Perricone and Rajiv Jalan

13 Assessment and Management of the Transplant Candidate with Alcohol-Associated Liver Disease 96Stéphanie Faure, Magdalena Meszaros, Lucy Meunier, Hélène Donnadieu-Rigole, and Georges-Philippe Pageaux

14 Non-alcoholic Fatty Liver Disease as an Indication for Liver Transplantation 104Paul Horn and Philip N. Newsome

15 Consent 109Christopher J.E. Watson

16 Prehabilitation and General Management 116Matthew J. Armstrong and Felicity R. Williams

17 Removal of Patients from the Liver Transplant Waiting List 123John OGrady

18 Palliative Care and Liver Transplantation 126Mina Rakoski and Puneeta Tandon

Part 3 Transplantation for Acute Liver Failure135

19 Assessment of the Patient with Acute Liver Failure 137Ashley Barnabas and John OGrady

20 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation 143Robert J. Fontana

Part 4 Donation and Allocation153

21 Ethical and Legal Aspects of Organ Donation 155Jessica Mellinger

22 Liver Allocation, Including Principles of Organ Allocation 161Parita Patel and Michael Charlton

23 Living Donor Liver Transplant in Children 168Adebowale A. Adeyemi, Elizabeth B. Rand, and Kim M. Olthoff

24 Living Liver Donation in Adults 180Mohamed Rela and Ashwin Rammohan

25 Deceased Liver Donors: Standard and Expanded Criteria 190Shareef Syed and Sandy Feng

26 Donor-Transmitted Disease 203James Neuberger

27 Liver Donation and Preservation 209Navneet Tiwari and Hynek Mergental

28 Liver Retrieval and Preservation 223Carlo D.L. Ceresa, Brian R. Davidson, Peter J. Friend, and Rutger J. Ploeg

29 Alternatives to Whole Graft Liver Transplantation 236Paolo Muiesan, Alessandro Parente, and Hector Vilca-Melendez

30 Surgical Aspects of Deceased Donor Transplantation 252Amit Nair, K.V. Narayanan Menon, Cristiano Quintini, and Charles Miller

Part 5 Care of the Liver Transplant Recipient265

31 Outcomes after Liver Transplantation 267James Neuberger

32 Outpatient Follow-Up of Liver Transplant Recipients 276Amardeep Khanna and James Ferguson

33 Medication Adherence 285Maureen Whitsett and Josh Levitsky

34 Transitional Care 299Fiona Thompson

35 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests 303Joanna A. Leithead

36 The Immune System in Liver Transplantation: Rejection versus Tolerance 317Palak J. Trivedi and Nick D. Jones

37 Immunosuppressive Medications: Liver Transplantation 334Tim Mitchell and Gerry MacQuillan

38 Immunosuppression in Liver Transplantation 344Nicholas Lim and John R. Lake

39 Patterns of Liver Allograft Rejection 353Geoffrey W. McCaughan, Ken Liu, Avik Majumdar, Patrick Bertolino, David G. Bowen, and Simone I. Strasser

40 De Novo Autoimmune Hepatitis 360James Neuberger

41 Managing Rejection 364Neil Halliday and Douglas Thorburn

42 Withdrawal of Immunosuppression after Liver Transplantation 386Luca Toti, Tommaso Maria Manzia, Francesca Blasi, and Giuseppe Tisone

43 Liver Transplant Pathology 393Owen L. Cain and Stefan G. Hübscher

44 Care of the Liver Transplant Recipient: Management of Renal Function 403Andres F. Carrion and Paul Martin

45 Managing Cardiovascular Risk in the Liver Transplant Recipient 409Manhal Izzy and Kymberly D. Watt

46 Bone Disease in Liver Transplantation 418John Ayuk

47 Diagnosis and Management of Recurrent Autoimmune Liver Disease 424Fernanda Q. Onofrio, Nazia Selzner, and Gideon M. Hirschfield

48 NAFLD and NASH in the Patient after Liver Transplantation 438Paul Horn and Philip N. Newsome

49 Recurrent Metabolic Diseases 445James Neuberger

50 Treatment of Hepatitis C in the Transplant Setting 449Jeffrey Kahn and Norah A. Terrault

51 Management of Hepatitis B Virus Infection Post Transplantation 458Bruno Roche and Didier Samuel

52 Antimicrobial Prophylaxis Following Liver Transplantation 469Michael J. Williams and Peter C. Hayes

53 Cytomegalovirus and the Liver Transplant Recipient 475James Ferguson

54 Post-Liver Transplant Infections 481Miruna David and Ahmed Elsharkawy

55 De Novo Malignancies after Liver Transplantation 493Simone I. Strasser, Ken Liu, Avik Majumdar, and Geoffrey W. McCaughan

56 Post-Transplant Lymphoproliferative Disorders 500Jose Ignacio Herrero

57 Quality of Life and Employment after Liver Transplantation 507Santiago Tome, Esteban Otero, and Michael Ronan Lucey

58 Sexual Function, Fertility, and Pregnancy in Liver Disease and after Liver Transplantation 514Patrizia Burra, Salvatore Stefano Sciarrone, and Patrizio Bo

59 Common Drug Interactions 519Amanda Smith

60 Immunization and Liver Transplantation 525Jessica Hause and Erin Spengler

Postscript 529James Neuberger

Index 531