26 real-life cases illustrate the applications of basic immunology in clinical settingsMay be utilized alone or as a companion toImmunology: A Short Course, 7th Edition by Richard Coico and Geofftry Sunshine (ISBN 9781118396919)Each case study is introduced by clearly written descriptions of the major immunological disordersFull colour photographs and illustrations complement complete presentation of real dataIncludes complete set of problems and discussion questions for each chapter
Preface, ix
Contributors, xi
Index of Lessons in Normal Immunity, xiii
INTRODUCTION TO CASE STUDIES: A GUIDE TO USING THIS BOOK, 1
Unit I IMMUNODEFICIENCY DISEASES, 3
INTRODUCTION: ORGANIZATION OF THE IMMUNE SYSTEM AND EVALUATION OF THE IMMUNODEFICIENT PATIENT, 5
1 X-LINKED AGAMMAGLOBULINEMIA (BRUTONS AGAMMAGLOBULINEMIA), 15
2 SEVERE COMBINED IMMUNODEFICIENCY DISEASE, 27
3 DiGEORGE SYNDROME (CONGENITAL THYMIC APLASIA), 41
4 HYPER-IgM SYNDROME, 53
5 COMMON VARIABLE IMMUNODEFICIENCY DISEASE, 67
6 AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME (ALPS), 81
7 X-LINKED LYMPHOPROLIFERATIVE SYNDROME, 91
8 HEREDITARY ANGIOEDEMA, 101
9 ACQUIRED IMMUNODEFICIENCY SYNDROME, 111
Unit II IMMEDIATE HYPERSENSITIVITY AND MAST CELL DISORDERS, 125
INTRODUCTION: WHEN ANTIGENS BECOME ALLERGENS, 127
10 MASTOCYTOSIS, 129
11 ANAPHYLAXIS, 137
12 ASTHMA, 147
13 THE VASCULITIDES, 161
Unit III AUTOIMMUNE DISORDERS, 173
INTRODUCTION: OVERVIEW OF AUTOIMMUNE DISORDERS AND MECHANISMS OF TOLERANCE, 175
14 MYASTHENIA GRAVIS, 183
15 MULTIPLE SCLEROSIS, 195
16 DIABETES MELLITUS TYPE 1, 207
17 CELIAC DISEASE, 219
18 INFLAMMATORY BOWEL DISEASE, 231
19 PSORIASIS, 245
20 IgA NEPHROPATHY AND KIDNEY TRANSPLANTATION, 255
21 RHEUMATOID ARTHRITIS, 269
22 SYSTEMIC LUPUS ERYTHEMATOSUS, 283
23 SCLERODERMA, 299
Unit IV MALIGNANCIES OF THE LYMPHOID SYSTEM, 309
INTRODUCTION: CLASSIFICATION OF LYMPHOID MALIGNANCIES, 311
24 CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA, 317
25 FOLLICULAR LYMPHOMA, 327
26 PLASMA CELL NEOPLASMS, 337
Unit V 349
LABORATORY TESTS USED IN THE WORKUP OF PATIENTS WITH IMMUNOLOGIC DISEASES, 351
Index, 369
