Mollison's Blood Transfusion in Clinical Medicine is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field.

Harvey Klein is Chief, Department of Transfusion Medicine, NIH Warren Grant Magnuson Clinical Centre and past-President of the American Association of Blood Banks. He is a recognized leader in defining transfusion medicine as a broader-based clinical and laboratory consultative subspecialty. Dr. Klein has published widely, authoring or co-authoring more than 150 publications, including journal articles and book chapters on transfusion medicine in major textbooks on hematology, internal medicine, and blood banking. He is on the editorial boards ofTransfusion andTransfusion Medicine Reviews.

Professor David Anstee is the Director of the Bristol Institute for Transfusion Sciences, as affiliated Institute of the University of Bristol which includes the International Blood Group Reference Laboratory, a World Health Organisation Collaborating Centre. He is also the Research co-ordinator for the National Blood Service in England and the former editor of the journal,Transfusion Medicine.

Preface to twelfth edition v

Preface to eleventh edition vii

Preface to first edition ix

In memoriam: Professor Mollison xi

1 Blood donors and the withdrawal of blood 1

2 Transfusion of blood, blood components and plasma alternatives in oligaemia 22

3 Immunology of red cells 53

4 ABO, H, LE, P1PK, GLOB, I and FORS blood group systems 118

5 The Rh blood group system (including LW and RHAG) 167

6 Other red cell antigens 214

7 Red cell antibodies against self-antigens, bound antigens and induced antigens 259

8 Blood grouping techniques 303

9 The transfusion of red cells 356

10 Red cell incompatibility in vivo 411

11 Haemolytic transfusion reactions 458

12 Haemolytic disease of the fetus and the newborn 499

13 Immunology of leucocytes, platelets and plasma components 549

14 The transfusion of platelets, leucocytes, haematopoietic progenitor cells and plasma components 611

15 Some unfavourable effects of transfusion 660

16 Infectious agents transmitted by transfusion 696

17 Exchange transfusion and haemapheresis 764

18 Alternatives to allogeneic transfusion 800

19 Plasma fractionation and fractionation products 846

Appendices 873

Index 892

Colour plate section facing p. 148