Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders. These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence their effective management. This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classical and contemporary techniques to enable practitioners in neurology and neuropathology to better understanding of the disease processes underlying patients presentations and to formulate appropriate management plans.Peripheral Nerve Disorders: Pathology and Genetics is a valuable resource for neurologists, neuropathologists, pathologists, neurobiologists and geneticists.
Contributor list vii
Foreword x
Preface xi
Abbreviations xiii
1 Clinical assessment and classification of peripheral nerve diseases 1 Pierre Bouche
2 Combined muscle and nerve biopsy 12 Anne Vital
3 Cutaneous nerve biopsy 15 Claudia Sommer and Maria Nolano
4 Methods for examination of peripheral nerve 24 Juan M. Bilbao Douglas C. Anthony and Umberto De Girolami
5 Complications from nerve biopsy 30 Richard A.C. Hughes
6 Anatomy of the peripheral nerve 32 Rosalind King
7 Basic pathology of the peripheral nervous system 38 J. Michael Schröder and Joachim Weis
8 Introduction to the hereditary neuropathies 59 Joachim Weis and Jan Senderek
9 Autosomal dominant demyelinating CharcotMarieTooth (CMT1) neuropathies 62 Jean-Michel Vallat and Stéphane Mathis
10 Autosomal dominant neuropathy of the axonal CharcotMarieTooth type 2 72 J. Michael Schröder Joachim Weis and Jan Senderek
11 Autosomal recessive demyelinating or axonal CharcotMarieTooth neuropathy 85 Kristl G. Claeys Martin Lammens Jan Senderek and Joachim Weis
12 Dominant and recessive intermediate CMT (CMTDI and CMTRI) 102 Joachim Weis Andreas Roos Istvan Katona Kristl G. Claeys and Jan Senderek
13 X-linked neuropathy of the CharcotMarieTooth type 111 J. Michael Schröder and Jan Senderek
14 Hereditary sensory and autonomic neuropathy 119 Rosalind King
15 Hereditary neuropathy with liability to pressure palsy 126 Benjamin Ellezam
16 Familial amyloid polyneuropathy 131 Manuel Melo Pires Ricardo Taipa and António Guimarães
17 Peripheral neuropathies in mitochondrial disorders 138 Benoît Funalot
18 Giant axonal neuropathy 142 Robert Ouvrier and Manoj Menezes
19 Neuroaxonal dystrophy 146 Robert Ouvrier and Manoj Menezes
20 Peripheral nerve involvement in neurolipidoses 149 Robert Ouvrier and Manoj Menezes
21 Other hereditary neuropathies 158 Stéphane Mathis Meriem Tazir and Jean-Michel Vallat
22 Adult polyglucosan body disease 167 Alexander Lossos Or Kakhlon and Dov Soffer
23 Polyneuropathies associated with neurofibromatosis 172 Joachim Weis
24 Vasculitides 175 Michael P. Collins and P. James B. Dyck
25 Infectious and tropical neuropathies 196 Leila Chimelli and Jean-Michel Vallat
26 Sarcoid neuropathy 210 Anne Vital
27 GuillainBarré syndromes and chronic inflammatory demyelinating polyradiculoneuropathy 214 Laurent Magy
28 Diabetic neuropathies 224 Robert E. Schmidt
29 Neuropathies in metabolic diseases other than diabetes mellitus 233 Martin Lammens
30 Toxic neuropathies 238 Sebastian Brandner
31 Polyneuropathy associated with a monoclonal gammopathy 247 Yuichi Kawagashira Haruki Koike Jean-Michel Vallat and Gen Sobue
32 Paraneoplastic peripheral neuropathies 259 Jean-Christophe Antoine
33 Neuropathies in malnutrition and alcoholism 267 Martin Lammens
34 Critical illness polyneuropathy 273 Douglas C. Anthony and David Lacomis
35 Non-vasculitic ischemic neuropathies 276 Robert E. Schmidt
36 Traumatic and compressive lesions of peripheral nerves 280 Carlos Ortiz-Hidalgo and Roy O. Weller
37 Localized hypertrophic neuropathy intraneural perineurioma polyneuropathy with perineurial cell hyperplasia and minifascicular neuropathy 287 Joachim Weis
38 Neurolymphomatosis and rare focal or multifocal lesions 291 Joachim Weis
Index 294
