Mark Hallett, MD, Senior Investigator at National Institute of Neurological Disorders and Stroke (NINDS), Chief of the Medical Neurology Branch and Chief of Human Motor Control Section; Editor-in-Chief ofClinical Neurophysiology; Associate Editor ofBrain.

Werner Poewe, Chairman of the Department of Neurology at Medical University of Innsbruck; Editorial board member ofMovement Disorder,Journal of Neurology,Journal of Neural Transmission, andAktuelle Neurologie.

Preface ix

Contributors xi

Part I Parkinsons Disease and Parkinsonism

1 The Etiopathogenesis of Parkinsons Disease: Basic Mechanisms of Neurodegeneration 3C. Warren Olanow and Kevin McNaught

2 Physiology of Parkinsons Disease 25Shlomo Elias, Zvi Israel and Hagai Bergman

3 Pharmacology of Parkinsons Disease 37Jonathan M. Brotchie

4 The Treatment of Early Parkinsons Disease 49Olivier Rascol and Regina Katzenschlager

5 Treatment of Motor Complications in Advanced Parkinsons Disease 71Susan H. Fox and Anthony E. Lang

6 Managing the Non-Motor Symptoms of Parkinsons Disease 91Werner Poewe and Klaus Seppi

7 Surgery for Parkinsons Disease 121Jens Volkmann

8 Future Cell- and Gene-Based Therapies for Parkinsons Disease 145Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin

9 Parkinson-Plus Disorders 157Martin Köllensperger and Gregor K. Wenning

Part II Tremor Disorders

10 Essential Tremor 179Rodger J. Elble

11 Other Tremor Disorders 193Günther Deuschl

Part III Dystonia, Cramps, and Spasms

12 Pathophysiology of Dystonia 205Mark Hallett

13 General Management Approach to Dystonia 217Cynthia L. Comella

14 Botulinum Toxin for Treatment of Dystonia 227Dirk Dressler

15 Surgical Treatments of Dystonia 241Christopher Kenney and Joseph Jankovic

16 Wilsons Disease 251George J. Brewer

17 Cramps and Spasms 263Christine D. Esper, Pratibha G. Aia, Leslie J. Cloud and Stewart A. Factor

18 Stiff Person Syndrome 283Philip D. Thompson and Hans-Michael Meinck

Part IV Chorea, Tics and other Movement Disorders

19 Huntingtons Disease 295Kevin M. Biglan and Ira Shoulson

20 Chorea 317Francisco Cardoso

21 Treatment of Tics and Tourette Syndrome 331Harvey S. Singer and Erika L.F. Hedderick

22 Therapeutics of Paroxysmal Dyskinesias 345Shyamal H. Mehta and Kapil D. Sethi

23 Treatment of Miscellaneous Disorders 353Marie Vidailhet, Emmanuel Roze and David Grabli

24 Myoclonus 363Shu-Ching Hu, Steven J. Frucht and Hiroshi Shibasaki

Part V Drug-induced Movement Disorders

25 Neuroleptic-Induced Movement Disorders 373S. Elizabeth Zauber and Christopher G. Goetz

26 Other Drug-Induced Dyskinesias 389Oscar S. Gershanik

Part VI Ataxia and Disorders of Gait and Balance

27 Ataxia 407Thomas Klockgether

28 Treatment of Gait and Balance Disorders 417Bastiaan R. Bloem, Alexander C. Geurts, S. Hassin-Baer and Nir Giladi

Part VII Restless Legs Syndrome

29 The Restless Legs Syndrome 447Richard P. Allen and Birgit H¤ogl

Part VIII Pediatric Movement Disorders

30 Pediatric Movement Disorders 471Jonathan W. Mink

Part IX Psychogenic Movement Disorders

31 Psychogenic Movement Disorders 479Elizabeth Peckham and Mark Hallett

Index 489