Sepsis: New Insights, New Therapiesbrings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response.Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat itDescribes numerous pharmacological approaches to therapy for early and late sepsisIncludes detailed discussion of the various physiological systems implicated in sepsisPresents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis

Sepsis: New Insights, New Therapiesis an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.

TheNovartis Foundationis an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.Chairman: Mitchell Fink

Symposim on Sepsis: new insights, new therapies, held at the Novartis Foundation, London, 14-16 February 2006.

Editors: Derek J. Cahdwick (Organizer) and Jamie Goode.

This Symposim was based on a proposal made by Mitchell Fink and Mervyn Singer.

Chairs introduction(Mitchell P. Fink).

Discussion.

Strategies to modulate cellular energetic metabolism during sepsis(Alessandro ProttiandMervyn Singer).

Discussion.

Immunostimulation is a rational therapeutic strategy in sepsis(Jérôme Pugin).

Discussion.

Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis(Alfred Ayala, Doreen E. Wesche-Soldato, Mario Perl, Joanne L. Lomas-Neira, Ryan SwanandChun-Shiang Chung).

Discussion.

Modulating neutrophil apoptosis(John C. Marshall, Zeenat MalamandSonghui Jia).

Discussion.

HMGB1 as a potential therapeutic target(Haichao Wang, Wei Li, Richard Goldstein, Kevin J. TraceyandAndrew E. Sama).

Discussion.

Poly (ADP-ribose) polymerase activation and circulatory shock(Csaba Szabó).

Discussion.

Choosing the right substrate(Xavier Leverve, Cécile BatandierandEric Fontaine).

Discussion.

Inhibiting glycogen synthase kinase 3? in sepsis(Laura Dugo, Marika Collin, David A. Allen, Nimesh S.A. Patel, Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. YaqoobandChristoph Thiemermann).

Discussion.

Ethyl pyruvate: a novel treatment for sepsis(Mitchell P. Fink).

Discussion.

General discussion I.

Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models(Stefan W. Ryter and Augustine M. K. Choi).

Discussion.

The hypothalamic pituitary adrenal axis in sepsis (Andrea Polito, Jérôme AboabandDjillali Annane).

Discussion.

Modulating the endocrine response in sepsis: insulin and blood glucose control(Ilse Vanhorebeek, Lies LangoucheandGreet Van den Berghe).

Discussion.

The neuronal strategy for inflammation(Luis UlloaandPing Wang).

Discussion.

Beta-blockade in burns(C. T. Pereira, M. G. JeschkeandD. N. Herndon).

Discussion.

System interactions(Mervyn Singer).

Discussion.

Protecting the permeability pore and mitochondrial biogenesis(C. A. Piantadosi, M. S. Carraway, D. W. HadenandH. B. Suliman).

Discussion.

Contributor Index.

Subject index.